Valproate (All indications)

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9330
R32538		 Artama (Valproate), 2005 Eye 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 1.19 [0.05;29.31] C 0/263   1/939 1 263
ref
S9299
R32367		 Dean (Valproate), 2002 Any eye disorder at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.37 [0.09;1.60] C 3/46   6/38 9 46
ref
Total 2 studies 0.45 [0.12;1.72] 10 309
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Valproate), 2005Artama, 2005 1 1.19[0.05; 29.31]126317%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Dean (Valproate), 2002Dean, 2002 2 0.37[0.09; 1.60]94683%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.45[0.12; 1.72]103090.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate; 2: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.12; 1.72]103090%NAArtama (Valproate), 2005 Dean (Valproate), 2002 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.45[0.12; 1.72]103090%NAArtama (Valproate), 2005 Dean (Valproate), 2002 2 Tags Adjustment   - No  - No 0.45[0.12; 1.72]103090%NAArtama (Valproate), 2005 Dean (Valproate), 2002 2 All studiesAll studies 0.45[0.12; 1.72]103090%NAArtama (Valproate), 2005 Dean (Valproate), 2002 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.12; 1.72]103090%NAArtama (Valproate), 2005 Dean (Valproate), 2002 20.510.01.0