Valproate (All indications)

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9299
R32356		 Dean (Valproate), 2002 Minor congenital malformations at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 7.50 [2.49;22.56] C 25/47   5/38 30 47
ref
S9332
R32556		 Battino (Valproate), 1992 Minor anomalies 1st trimester prospective cohort unexposed, sick Adjustment: No 7.62 [0.38;152.84] C 6/21   0/9 6 21
ref
S9352
R32721		 Robert (Valproate), 1986 Minor malformations 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.94 [0.38;9.97] C 3/15   4/35 7 15
ref
Total 3 studies 5.11 [2.13;12.25] 43 83
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dean (Valproate), 2002Dean, 2002 1 7.50[2.49; 22.56]304763%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Battino (Valproate), 1992Battino, 1992 2 7.62[0.38; 152.84]6219%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Robert (Valproate), 1986Robert, 1986 3 1.94[0.38; 9.97]71528%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 5.11[2.13; 12.25]43830.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate; 2: Valproate; 3: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.11[2.13; 12.25]43830%NADean (Valproate), 2002 Battino (Valproate), 1992 Robert (Valproate), 1986 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 5.11[2.13; 12.25]43830%NADean (Valproate), 2002 Battino (Valproate), 1992 Robert (Valproate), 1986 3 Tags Adjustment   - No  - No 5.11[2.13; 12.25]43830%NADean (Valproate), 2002 Battino (Valproate), 1992 Robert (Valproate), 1986 3 All studiesAll studies 5.11[2.13; 12.25]43830%NADean (Valproate), 2002 Battino (Valproate), 1992 Robert (Valproate), 1986 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 5.11[2.13; 12.25]43830%NADean (Valproate), 2002 Battino (Valproate), 1992 Robert (Valproate), 1986 30.510.01.0