Valproate (All indications)

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15246
R62690		 Ren (Valproate) (Mixed indications), 2023 Danish at 9th grade - Mean age 16.1 (SD 0.4) years during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes extrapolated (cont. endpoint) 1.27 [1.00;1.60] -/232   -/370,569 - 232
ref
Total 1 studies 1.27 [1.00;1.61] 0 232
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ren (Valproate) (Mixed indications), 2023Ren, 2023 1 1.27[1.00; 1.60]-2320%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 1 Tags Adjustment   - Yes  - Yes 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 1 All studiesAll studies 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[1.00; 1.61]-232 -NARen (Valproate) (Mixed indications), 2023 10.510.01.0