Valproate (All indications)

Fonctions exécutives (A CONSOLIDER)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9414
R33013		 Meador (Valproate), 2013 Executive index (averaging NEPSY subtests) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: Yes extrapolated (cont. endpoint) 2.70 [1.39;5.27] -/49   -/74 - 49
ref
S9450
R33210		 Rihtman (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2013 Behavior Rating Inventory of Executive Function Global Executive Composite (BRIEF GEC) - Parent rating (mean age 4-5 years old) at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Controls: epilepsy indication extrapolated (cont. endpoint) 1.72 [0.71;4.17]
excluded (control group) 		-/28   -/39 - 28
ref
S9451
R33245		 Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 Behavior Rating Inventory of Executive Function Global Executive Composite (BRIEF GEC) - Parent rating (mean age 4-5 years old) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) 2.87 [1.23;6.72] -/28   -/52 - 28
ref
Total 2 studies 2.76 [1.64;4.67] 0 77
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meador (Valproate), 2013Meador, 2013 1 2.70[1.39; 5.27]-4962%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: moderateROB mesure: lowROB reporting: low Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013Rihtman, 2013 2 2.87[1.23; 6.72]-2838%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.76[1.64; 4.67]-770.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate; 2: Valproate) (Controls unexposed, NOS) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.76[1.64; 4.67]-770%NAMeador (Valproate), 2013 Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.87[1.23; 6.71]-28 -NARihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 1 exposed to other treatment, sickexposed to other treatment, sick 2.70[1.39; 5.26]-49 -NAMeador (Valproate), 2013 1 Tags Adjustment   - No  - No 2.87[1.23; 6.71]-28 -NARihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 1   - Yes  - Yes 2.70[1.39; 5.26]-49 -NAMeador (Valproate), 2013 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 2.76[1.64; 4.67]-770%NAMeador (Valproate), 2013 Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 2 All studiesAll studies 2.76[1.64; 4.67]-770%NAMeador (Valproate), 2013 Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9450

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.87[1.23; 6.71]-28 -NARihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.29[1.35; 3.91]-770%NAMeador (Valproate), 2013 Rihtman (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2013 20.510.01.0