Valproate (All indications)

Valproate syndrome

id	Study   Auto Dean (Valproate) (Controls exposed to Lamotrigine, sick), 2007Dean (Valproate) (Controls unexposed, sick), 2007	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9339 R32586	Dean (Valproate) (Controls exposed to Lamotrigine, sick), 2007	Fetal anticonvulsant syndrome	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	5.38 [0.27;108.67] C excluded (control group)	26/61   0/4	26	61		ref
S9340 R32588	Dean (Valproate) (Controls unexposed, sick), 2007	Fetal anticonvulsant syndrome	during pregnancy (anytime or not specified) excluded	retrospective cohort	unexposed, sick	Adjustment: No	7.80 [2.48;24.49] C excluded (exposition period)	26/61   4/46	30	61		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis