Valproate (All indications)

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9385
R32847		 Christensen (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2013 Childhood autism (mean age almost 9 years old) during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 2.95 [0.86;10.16] C
excluded (control group) 		7/388   4/647 11 388
ref
S9387
R32851		 Christensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 Childhood autism (mean age almost 9 years old) during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes 4.90 [2.30;10.30] 7/388   2,058/655,107 2,065 388
ref
Total 1 studies 4.90 [2.32;10.37] 2,065 388
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013Christensen, 2013 1 4.90[2.30; 10.30]2,0653880%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.90[2.32; 10.37]2,065388 -NAChristensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.90[2.32; 10.37]2,065388 -NAChristensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 1 Tags Adjustment   - Yes  - Yes 4.90[2.32; 10.37]2,065388 -NAChristensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 1 All studiesAll studies 4.90[2.32; 10.37]2,065388 -NAChristensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9385

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.90[2.32; 10.37]2,065388 -NAChristensen (Valproate) (Controls unexposed NOS) (Mixed indications), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.95[0.86; 10.16]11388 -NAChristensen (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2013 10.510.01.0