id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9259 R32101 |
Cohen (Phenytoin), 2011 | Motor Index score (the Bayley Scales of Infant Development (BSID-II)) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: Yes extrapolated (cont. endpoint) | 0.60 [0.28;1.31] | -/32 -/62 | - | 32 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9268 R32146 |
Thomas b (Phenytoin), 2008 | Impaired Motor Development Quotient < 84 (The Developmental Assessment Scale (DAS II)) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 0.53 [0.16;1.83] C | 5/29 9/32 | 14 | 29 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9263 R32123 |
Koch (Phenytoin), 1996 | Minor neurological dysfunction (at age 6) (Touwen) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: No Matched | 0.83 [0.08;8.43] C | 1/10 4/34 | 5 | 10 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 0.60 [0.32;1.12] | 19 | 71 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenytoin; 2: Phenytoin; 3: Phenytoin;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded