id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S9246 R32081 |
Tomson (Phenytoin), 2018 | Neural tube defects | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 20.27 [1.26;325.93] C | 1/125 1/2,514 | 2 | 125 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10300 R37744 |
Vajda (Phenytoin) (Controls exposed to Lamotrigine, sick), 2013 | Neural Tube Malformations | at least 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
22.20 [0.89;553.77] C excluded (control group) |
1/44 0/315 | 1 | 44 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10301 R37757 |
Vajda (Phenytoin) (Controls unexposed, sick), 2013 | Neural Tube Malformations | at least 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 10.34 [0.41;258.52] C | 1/44 0/147 | 1 | 44 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10229 R37472 |
Hernández-Díaz (Phenytoin) (Controls exposed to Lamotrigine, sick), 2012 | Neural tube defects | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No Controls: mixed indications | 0.75 [0.04;15.67] C | 0/416 2/1,562 | 2 | 416 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9225 R32015 |
Bànhidy (Phenytoin), 2011 | Neural tube defects | throughout pregnancy | case control | unexposed, sick | Adjustment: No Matched | 0.53 [0.03;9.34] C | 1/20 1/11 | 2 | 20 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9209 R35366 |
Mawer (Phenytoin) (Controls exposed to Lamotrigine, sick), 2010 | Neural Tube Malformations | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
5.62 [0.10;309.00] C excluded (control group) |
0/7 0/37 | 0 | 7 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9210 R35370 |
Mawer (Phenytoin) (Controls unexposed, disease free), 2010 | Neural Tube Malformations | 1st trimester | prospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
14.54 [0.54;391.72] C excluded (control group) |
0/7 1/285 | 1 | 7 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9211 R35374 |
Mawer (Phenytoin) (Controls unexposed, sick), 2010 | Neural Tube Malformations | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 6.23 [0.11;342.42] C | 0/7 0/41 | 0 | 7 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9238 R32057 |
Morrow (Phenytoin) (Controls exposed to Lamotrigine, sick), 2006 | Neural tube defect | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 2.64 [0.11;65.35] C | 0/82 1/647 | 1 | 82 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 6 studies | 3.20 [0.89;11.45] | 8 | 694 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenytoin; 2: Phenytoin) (Controls unexposed, sick; 3: Phenytoin) (Controls exposed to Lamotrigine, sick; 4: Phenytoin; 5: Phenytoin) (Controls unexposed, sick; 6: Phenytoin) (Controls exposed to Lamotrigine, sick;
Asymetry test p-value = 0.8479 (by Egger's regression)
slope=-0.1267 (6.3432); intercept=0.8142 (3.9797); t=0.2046; p=0.8479
excluded 9209, 9210, 10300