Phenytoin (All indications)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9192
R31827		 Aydin (Phenytoin) (Controls exposed to Lamotrigine, sick), 2020 Preeclampsia/ eclampsia throughout pregnancy retrospective cohort exposed to other treatment, sick excluded Adjustment: No 13.00 [0.10;1680.94] C
excluded (control group) 		0/1   0/7 0 1
ref
S9193
R31837		 Aydin (Phenytoin) (Controls unexposed, sick), 2020 Preeclampsia/ eclampsia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 43.00 [0.35;5328.22] C 0/1   0/22 0 1
ref
S9216
R31977		 Pennell (Phenytoin), 2012 Gestational hypertension during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 1.13 [0.26;4.91] C 3/52   5/97 8 52
ref
Total 2 studies 3.28 [0.13;84.58] 8 53
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin (Phenytoin) (Controls unexposed, sick), 2020Aydin, 2020 1 43.00[0.35; 5328.22]0129%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Pennell (Phenytoin), 2012Pennell, 2012 2 1.13[0.26; 4.91]85271%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 50% 3.28[0.13; 84.58]8530.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin) (Controls unexposed, sick; 2: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.28[0.13; 84.58]85350%NAAydin (Phenytoin) (Controls unexposed, sick), 2020 Pennell (Phenytoin), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 43.00[0.35; 5328.22]-1 -NAAydin (Phenytoin) (Controls unexposed, sick), 2020 1 exposed to other treatment, sickexposed to other treatment, sick 1.13[0.26; 4.91]852 -NAPennell (Phenytoin), 2012 1 Tags Adjustment   - No  - No 3.28[0.13; 84.58]85350%NAAydin (Phenytoin) (Controls unexposed, sick), 2020 Pennell (Phenytoin), 2012 2 All studiesAll studies 3.28[0.13; 84.58]85350%NAAydin (Phenytoin) (Controls unexposed, sick), 2020 Pennell (Phenytoin), 2012 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9192

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale43.00[0.35; 5328.22]-1 -NAAydin (Phenytoin) (Controls unexposed, sick), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.38[0.34; 5.66]8530%NAAydin (Phenytoin) (Controls exposed to Lamotrigine, sick), 2020 Pennell (Phenytoin), 2012 20.510.01.0