id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S12836 R48366 |
Thomas (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2021 | Urinary malformations | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.12 [0.00;2.96] C excluded (control group) |
0/137 1/50 | 1 | 137 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12838 R48378 |
Thomas (Phenobarbital) (Controls unexposed, sick), 2021 | Urinary malformations | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 0.19 [0.01;3.36] C | 0/137 6/340 | 6 | 137 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9151 R31462 |
Tomson (Phenobarbital), 2018 | Renal malformations | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 1.07 [0.13;8.58] C | 1/294 8/2,514 | 9 | 294 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 0.59 [0.11;3.19] | 15 | 431 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenobarbital) (Controls unexposed, sick; 2: Phenobarbital;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 12836