id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S9098 R31163 |
Barroso (Phenobarbital), 2015 | Minor anomalies | during pregnancy (anytime or not specified) excluded | retrospective cohort | unexposed, disease free | Adjustment: No |
2.01 [0.23;17.72] C excluded (exposition period) |
1/32 5/316 | 6 | 32 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9103 R31235 |
Dean (Phenobarbital), 2002 | Minor congenital malformations | at least 1st trimester | retrospective cohort | unexposed, sick | Adjustment: No | 3.99 [1.37;11.69] C | 23/61 5/38 | 28 | 61 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9125 R31351 |
Battino (Phenobarbital), 1992 | Minor anomalies | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 2.43 [0.13;46.54] C | 7/60 0/9 | 7 | 60 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9172 R31561 |
Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 | Waldrop score >2 | throughout pregnancy | prospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
4.50 [1.20;16.89] C excluded (control group) |
6/12 10/55 | 16 | 12 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9173 R31586 |
Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 | Waldrop score >2 | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 1.20 [0.29;4.91] C | 6/12 10/22 | 16 | 12 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9144 R31443 |
Robert (Phenobarbital), 1986 | Minor malformations | 1st trimester | retrospective cohort | unexposed, sick | Adjustment: No | 0.86 [0.20;3.73] C | 4/40 4/35 | 8 | 40 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 1.92 [0.88;4.18] | 59 | 173 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenobarbital; 2: Phenobarbital; 3: Phenobarbital) (Controls unexposed, sick; 4: Phenobarbital;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded 9172