Phenobarbital (All indications)

Cognitive developmental disorders/delay (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9169
R53636		 Thomas b (Phenobarbital), 2008 Impaired Mental Development Quotient < 84 (The Developmental Assessment Scale (DAS II)) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.81 [0.29;2.23] C 11/41   10/32 21 41
ref
S9179
R53635		 Shankaran (Phenobarbital) (Other indications), 2002 The mental developmental index ≤84 (MDI) (Bayley) days before delivery excluded randomized controlled trial unexposed, sick Adjustment: Randomisation 1.18 [0.80;1.75] C
excluded (exposition period) 		105/214   84/187 189 214
ref
S9132
R53634		 Kelly (Phenobarbital), 1984 Delayed development during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.20 [0.01;4.23] C 0/13   3/21 3 13
ref
Total 2 studies 0.70 [0.27;1.84] 24 54
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas b (Phenobarbital), 2008Thomas b, 2008 1 0.81[0.29; 2.23]214190%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: lowROB reporting: moderate Kelly (Phenobarbital), 1984Kelly, 1984 2 Out of scale0.20[0.01; 4.23]31310%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.70[0.27; 1.84]24540.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital; 2: Phenobarbital;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.70[0.27; 1.84]24540%NAThomas b (Phenobarbital), 2008 Kelly (Phenobarbital), 1984 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.70[0.27; 1.84]24540%NAThomas b (Phenobarbital), 2008 Kelly (Phenobarbital), 1984 2 Tags Adjustment   - No  - No 0.70[0.27; 1.84]24540%NAThomas b (Phenobarbital), 2008 Kelly (Phenobarbital), 1984 2 All studiesAll studies 0.70[0.27; 1.84]24540%NAThomas b (Phenobarbital), 2008 Kelly (Phenobarbital), 1984 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.70[0.27; 1.84]24540%NAThomas b (Phenobarbital), 2008 Kelly (Phenobarbital), 1984 20.510.01.0