Phenobarbital (All indications)

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9169
R31549		 Thomas b (Phenobarbital), 2008 Impaired Motor Development Quotient < 84 (The Developmental Assessment Scale (DAS II)) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.53 [0.17;1.61] C 7/41   9/32 16 41
ref
S9179
R31634		 Shankaran (Phenobarbital) (Other indications), 2002 The psychomotor developmental index ≤84 (PDI) (Bayley) days before delivery excluded randomized controlled trial unexposed, sick Adjustment: Randomisation 0.79 [0.51;1.22] C
excluded (exposition period) 		59/206   61/181 120 206
ref
S9167
R31544		 Koch (Phenobarbital), 1996 Minor neurological dysfunction (at age 6) (Touwen) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.94 [0.04;21.31] C 0/4   4/34 4 4
ref
Total 2 studies 0.56 [0.20;1.61] 20 45
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas b (Phenobarbital), 2008Thomas b, 2008 1 0.53[0.17; 1.61]164189%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: lowROB reporting: moderate Koch (Phenobarbital), 1996Koch, 1996 2 0.94[0.04; 21.31]4411%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.56[0.20; 1.61]20450.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital; 2: Phenobarbital;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.56[0.20; 1.61]20450%NAThomas b (Phenobarbital), 2008 Koch (Phenobarbital), 1996 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.04; 21.31]44 -NAKoch (Phenobarbital), 1996 1 unexposed, sickunexposed, sick 0.53[0.17; 1.61]1641 -NAThomas b (Phenobarbital), 2008 1 Tags Adjustment   - No  - No 0.56[0.20; 1.61]20450%NAThomas b (Phenobarbital), 2008 Koch (Phenobarbital), 1996 2 MatchedMatched 0.94[0.04; 21.31]44 -NAKoch (Phenobarbital), 1996 1 All studiesAll studies 0.56[0.20; 1.61]20450%NAThomas b (Phenobarbital), 2008 Koch (Phenobarbital), 1996 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.04; 21.31]44 -NAKoch (Phenobarbital), 1996 1 unexposed, sick controlsunexposed, sick controls 0.53[0.17; 1.61]1641 -NAThomas b (Phenobarbital), 2008 10.510.01.0