Phenobarbital (All indications)

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9099
R31166		 Burja (Phenobarbital) (Controls unexposed, disease free), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 37.36 [0.68;2061.38] C
excluded (control group) 		0/1   5/211 5 1
ref
S9100
R31171		 Burja (Phenobarbital) (Controls unexposed, sick), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 11.80 [0.19;731.60] C 0/1   2/32 2 1
ref
S9179
R31637		 Shankaran (Phenobarbital) (Other indications), 2002 Intracranial Hemorrhage (all grade) days before delivery randomized controlled trial unexposed, sick Adjustment: Randomisation 1.00 [0.64;1.57] C 51/225   47/207 98 225
ref
S9101
R31197		 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 17.57 [0.30;1024.08] C
excluded (control group) 		0/4   0/62 0 4
ref
S9102
R31226		 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.14 [0.03;131.94] C 0/4   0/8 0 4
ref
Total 3 studies 1.04 [0.66;1.62] 100 230
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Phenobarbital) (Controls unexposed, sick), 2006Burja, 2006 1 11.80[0.19; 731.60]211%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Shankaran (Phenobarbital) (Other indications), 2002Shankaran, 2002 2 1.00[0.64; 1.57]9822598%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Phenobarbital) (Controls unexposed, sick), 1991D'Souza, 1991 3 2.14[0.03; 131.94]041%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.04[0.66; 1.62]1002300.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick; 2: Phenobarbital) (Other indications; 3: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.02[0.27; 92.72]250%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 RCTRCT 1.00[0.64; 1.57]98225 -NAShankaran (Phenobarbital) (Other indications), 2002 1 Type of controls unexposed, sickunexposed, sick 1.04[0.66; 1.62]1002300%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Shankaran (Phenobarbital) (Other indications), 2002 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 3 Tags Adjustment   - No  - No 5.02[0.27; 92.72]250%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2   - Randomisation  - Randomisation 1.00[0.64; 1.57]98225 -NAShankaran (Phenobarbital) (Other indications), 2002 1 All studiesAll studies 1.04[0.66; 1.62]1002300%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Shankaran (Phenobarbital) (Other indications), 2002 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 30.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9101, 9099

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale25.75[1.48; 447.47]550%NABurja (Phenobarbital) (Controls unexposed, disease free), 2006 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 1.04[0.66; 1.62]1002300%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Shankaran (Phenobarbital) (Other indications), 2002 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 30.510.01.0