Phenobarbital (All indications)

Feeding difficulty

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9099
R31169
Burja (Phenobarbital) (Controls unexposed, disease free), 2006 Feeding problems during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 27.13 [0.50;1462.54] C
excluded (control group)
0/1   7/211 7 1
ref
S9100
R31174
Burja (Phenobarbital) (Controls unexposed, sick), 2006 Feeding problems during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 20.33 [0.29;1423.95] C 0/1   1/32 1 1
ref
S9154
R31468
Yerby (Phenobarbital), 1992 Feeding difficulties during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No 5.00 [0.29;87.55] C 1/10   1/46 2 10
ref
S9101
R31191
D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Feeding difficulty (tube fed) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 17.57 [0.30;1024.08] C
excluded (control group)
0/4   0/62 0 4
ref
S9102
R31220
D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Feeding difficulty (tube fed) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.14 [0.03;131.94] C 0/4   0/8 0 4
ref
Total 3 studies 5.62 [0.72;44.00] 3 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Phenobarbital) (Controls unexposed, sick), 2006Burja, 2006 1 20.33[0.29; 1423.95]1123%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Yerby (Phenobarbital), 1992Yerby, 1992 2 5.00[0.29; 87.55]21052%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Phenobarbital) (Controls unexposed, sick), 1991D'Souza, 1991 3 2.14[0.03; 131.94]0425%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 5.62[0.72; 44.00]3150.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick; 2: Phenobarbital; 3: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.62[0.72; 44.00]3150%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Yerby (Phenobarbital), 1992 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.00[0.29; 87.55]210 -NAYerby (Phenobarbital), 1992 1 unexposed, sickunexposed, sick 6.38[0.33; 122.79]150%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 5.62[0.72; 44.00]3150%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Yerby (Phenobarbital), 1992 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 3 All studiesAll studies 5.62[0.72; 44.00]3150%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 Yerby (Phenobarbital), 1992 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 30.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9101, 9099

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.51[1.40; 79.15]9150%NABurja (Phenobarbital) (Controls unexposed, disease free), 2006 Yerby (Phenobarbital), 1992 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 3 unexposed, sick controlsunexposed, sick controls 6.38[0.33; 122.79]150%NABurja (Phenobarbital) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0