Phenobarbital (All indications)

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9155
R31472		 Tomson (Phenobarbital), 2015 Perinatal death (during the first week after delivery from gestational week 24) at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 1.06 [0.05;20.55] C 0/238   3/1,763 3 238
ref
S9126
R31356		 Canger (Phenobarbital), 1999 Perinatal deaths (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 0.30 [0.01;15.36] C 0/83   0/25 0 83
ref
Total 2 studies 0.67 [0.06;7.16] 3 321
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tomson (Phenobarbital), 2015Tomson, 2015 1 1.06[0.05; 20.55]323864%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Canger (Phenobarbital), 1999Canger, 1999 2 0.30[0.01; 15.36]08336%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.67[0.06; 7.16]33210.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital; 2: Phenobarbital;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.67[0.06; 7.16]33210%NATomson (Phenobarbital), 2015 Canger (Phenobarbital), 1999 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.30[0.01; 15.36]-83 -NACanger (Phenobarbital), 1999 1 exposed to other treatment, sickexposed to other treatment, sick 1.06[0.05; 20.55]3238 -NATomson (Phenobarbital), 2015 1 Tags Adjustment   - No  - No 0.67[0.06; 7.16]33210%NATomson (Phenobarbital), 2015 Canger (Phenobarbital), 1999 2 All studiesAll studies 0.67[0.06; 7.16]33210%NATomson (Phenobarbital), 2015 Canger (Phenobarbital), 1999 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.30[0.01; 15.36]-83 -NACanger (Phenobarbital), 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.05; 20.55]3238 -NATomson (Phenobarbital), 2015 10.510.01.0