Phenobarbital (All indications)

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9104
R31263		 Endo (Phenobarbital) (Controls unexposed, disease free), 2004 Apgar score (<8 at 1min) throughout pregnancy retrospective cohort unexposed, disease free excluded Adjustment: No 0.26 [0.01;4.50] C
excluded (control group) 		0/10   47/280 47 10
ref
S9105
R31278		 Endo (Phenobarbital) (Controls unexposed, sick), 2004 Apgar score (<8 at 1min) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.05 [0.00;6.68] C 0/10   0/1 0 10
ref
S9172
R31552		 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 Apgar scores (1 minute <7) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 0.91 [0.10;8.57] C
excluded (control group) 		1/12   5/55 6 12
ref
S9173
R31577		 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 Apgar scores (1 minute <7) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 1.91 [0.11;33.54] C 1/12   1/22 2 12
ref
Total 2 studies 0.55 [0.02;15.67] 2 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Endo (Phenobarbital) (Controls unexposed, sick), 2004Endo, 2004 1 0.05[0.00; 6.68]01035%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991Van der Pol, 1991 2 1.91[0.11; 33.54]21265%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 36% 0.55[0.02; 15.67]2220.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick; 2: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.55[0.02; 15.67]22236%NAEndo (Phenobarbital) (Controls unexposed, sick), 2004 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.55[0.02; 15.67]22236%NAEndo (Phenobarbital) (Controls unexposed, sick), 2004 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 0.55[0.02; 15.67]22236%NAEndo (Phenobarbital) (Controls unexposed, sick), 2004 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 All studiesAll studies 0.55[0.02; 15.67]22236%NAEndo (Phenobarbital) (Controls unexposed, sick), 2004 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9172, 9104

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.56[0.10; 3.29]53220%NAEndo (Phenobarbital) (Controls unexposed, disease free), 2004 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 0.55[0.02; 15.67]22236%NAEndo (Phenobarbital) (Controls unexposed, sick), 2004 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0