id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9151 R31461 |
Tomson (Phenobarbital), 2018 | Polydactyly | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 43.11 [2.06;900.25] C | 2/294 0/2,514 | 2 | 294 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9124 R31349 |
Bànhidy (Phenobarbital), 2011 | Poly/syndactyly | throughout pregnancy | case control | unexposed, sick | Adjustment: No Matched | 6.33 [0.09;458.24] C | 0/ 2/12 | 2 | 0 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9101 R31179 |
D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 | Extra digits | throughout pregnancy | prospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
17.57 [0.30;1024.08] C excluded (control group) |
0/4 0/62 | 0 | 4 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9102 R31208 |
D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 | Extra digits | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 2.14 [0.03;131.94] C | 0/4 0/8 | 0 | 4 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 12.12 [1.45;101.31] | 4 | 298 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenobarbital; 2: Phenobarbital; 3: Phenobarbital) (Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 9101