id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9151 R31460 |
Tomson (Phenobarbital), 2018 | Neural tube defects | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 17.21 [1.56;190.41] C | 2/294 1/2,514 | 3 | 294 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9107 R31283 |
Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 | Neural tube defects | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No Controls: mixed indications | 1.57 [0.08;32.85] C | 0/199 2/1,562 | 2 | 199 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9124 R31345 |
Bànhidy (Phenobarbital), 2011 | Neural tube defects | throughout pregnancy | case control | unexposed, sick | Adjustment: No Matched | 19.00 [0.15;2409.97] C | 0/ 1/11 | 1 | 0 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9126 R31355 |
Canger (Phenobarbital), 1999 | Neural tube defects | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 0.30 [0.01;15.36] C | 0/83 0/25 | 0 | 83 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 4.12 [0.63;26.77] | 6 | 576 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenobarbital; 2: Phenobarbital) (Controls exposed to Lamotrigine, sick; 3: Phenobarbital; 4: Phenobarbital;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded