id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S10171 R46497 |
Blotière (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 | Oro-facial clefts | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
2.40 [0.13;44.81] C excluded (control group) |
0/139 4/2,997 | 4 | 139 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10039 R46488 |
Blotière (Oxcarbazepine) (Controls unexposed NOS) (Mixed indications), 2019 | Oro-facial clefts | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 2.40 [0.15;38.60] C | 0/139 2,815/1,875,733 | 2,815 | 139 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9074 R31063 |
Tomson (Oxcarbazepine), 2018 | Cleft lip or palate | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 2.52 [0.26;24.31] C | 1/333 3/2,514 | 4 | 333 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9052 R30896 |
Veiby (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 | Orofacial clefts | throughout pregnancy | population based cohort retrospective | exposed to other treatment, sick | Adjustment: No | 4.91 [0.20;121.80] C | 0/57 1/833 | 1 | 57 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9062 R30935 |
Morrow (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2006 | Facial cleft | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 33.10 [1.23;890.88] C | 0/7 1/647 | 1 | 7 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 4.48 [1.11;18.10] | 2,821 | 536 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Oxcarbazepine) (Controls unexposed NOS) (Mixed indications; 2: Oxcarbazepine; 3: Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications; 4: Oxcarbazepine) (Controls exposed to Lamotrigine, sick;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded 10171