id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S10171 R37132 |
Blotière (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 | Spina bifida | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
7.21 [0.29;177.79] C excluded (control group) |
0/139 1/2,997 | 1 | 139 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10039 R36240 |
Blotière (Oxcarbazepine) (Controls unexposed NOS) (Mixed indications), 2019 | Spina bifida | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 10.98 [0.68;176.63] C | 0/139 616/1,875,733 | 616 | 139 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9052 R30895 |
Veiby (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 | Spina bifida | throughout pregnancy | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
14.73 [0.29;749.53] C excluded (control group) |
0/57 0/833 | 0 | 57 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9054 R30902 |
Veiby (Oxcarbazepine) (Controls unexposed, sick) (Mixed indications), 2014 | Spina bifida | throughout pregnancy | population based cohort retrospective | unexposed, sick | Adjustment: No Controls: epilepsy indication | 9.53 [0.49;186.68] C | 0/57 3/3,773 | 3 | 57 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9065 R30945 |
Viinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 | Spina bifida | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 34.33 [0.49;2389.88] C | 0/2 0/52 | 0 | 2 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9057 R30912 |
Artama (Oxcarbazepine), 2005 | Spina bifida | 1st trimester | retrospective cohort (registry) | unexposed, sick | Adjustment: No | 9.53 [0.19;482.86] C | 0/99 0/939 | 0 | 99 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 12.20 [2.32;64.13] | 619 | 297 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Oxcarbazepine) (Controls unexposed NOS) (Mixed indications; 2: Oxcarbazepine) (Controls unexposed, sick) (Mixed indications; 3: Oxcarbazepine) (Controls unexposed, sick) ; 4: Oxcarbazepine;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded 9052, 10171