Lamotrigine (All indications) - Medication and Pregnancy KB

Lamotrigine (All indications)

Emotional disorders

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15229 R62521	Dreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023	Anxiety disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age	during pregnancy (anytime or not specified)	population based cohort propective	unexposed, sick	Adjustment: Yes	1.01 [0.80;1.27]	97/5,288 458/22,203	555	5,288		ref
S8941 R30230	Cohen-Israel (Lamotrigine), 2018	Emotional disturbance (a majority between 6-12 years old)	1st trimester	retrospective cohort	unexposed, disease free	Adjustment: No Matched	5.12 [0.24;108.41] ^C	2/83 0/83	2	83		ref
					Total	2 studies	1.08 [0.57;2.07]		557	5,371
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Lamotrigine) (Epilepsy) (Controls unexposed, sick; 2: Lamotrigine;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded