id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S10035 R36148 |
Blotière (Lamotrigine) (Mixed indications), 2019 | Spina bifida | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 1.02 [0.14;7.23] C | 1/2,997 616/1,875,733 | 617 | 2,997 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8965 R30362 |
Veiby (Lamotrigine) (Controls unexposed, sick) (Mixed indications), 2014 | Spina bifida | throughout pregnancy | population based cohort retrospective | unexposed, sick | Adjustment: No Controls: epilepsy indication | 0.65 [0.03;12.54] C | 0/833 3/3,773 | 3 | 833 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8905 R30090 |
Charlton (Lamotrigine), 2011 | Spina bifida | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: No | 1.85 [0.09;38.71] C | 0/98 2/902 | 2 | 98 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 1.04 [0.25;4.41] | 622 | 3,928 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Lamotrigine) (Mixed indications; 2: Lamotrigine) (Controls unexposed, sick) (Mixed indications; 3: Lamotrigine;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded