Lamotrigine (All indications)

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10292
R37688		 Vajda (Lamotrigine), 2013 Neural Tube Malformations at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.47 [0.01;23.59] C 0/315   0/147 0 315
ref
S8909
R35286		 Mawer (Lamotrigine) (Controls unexposed, disease free), 2010 Neural Tube Malformations 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No Matched 2.59 [0.10;64.75] C
excluded (control group) 		0/37   1/285 1 37
ref
S8910
R35290		 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 Neural Tube Malformations 1st trimester prospective cohort unexposed, sick Adjustment: No Matched 1.11 [0.02;57.36] C 0/37   0/41 0 37
ref
Total 2 studies 0.72 [0.04;11.59] 0 352
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vajda (Lamotrigine), 2013Vajda, 2013 1 0.47[0.01; 23.59]031550%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Mawer (Lamotrigine) (Controls unexposed, sick), 2010Mawer, 2010 2 1.11[0.02; 57.36]03750%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.72[0.04; 11.59]-3520.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine; 2: Lamotrigine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.72[0.04; 11.59]-3520%NAVajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.72[0.04; 11.59]-3520%NAVajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 2 Tags Adjustment   - No  - No 0.72[0.04; 11.59]-3520%NAVajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 2 MatchedMatched 1.11[0.02; 57.36]-37 -NAMawer (Lamotrigine) (Controls unexposed, sick), 2010 1 All studiesAll studies 0.72[0.04; 11.59]-3520%NAVajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8909

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.59[0.10; 64.75]137 -NAMawer (Lamotrigine) (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 0.72[0.04; 11.59]-3520%NAVajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 20.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period WestonWeston 2.57[0.11; 62.03]NA-unexposed, disease freeduring pregnancy (anytime or not specified)studies1 WestonWeston Out of scale0.00[0.00; 0.00]NA-unexposed, sickduring pregnancy (anytime or not specified)studies2 metaPregmetaPreg 0.72[0.04; 11.59]0%352--Vajda (Lamotrigine), 2013 Mawer (Lamotrigine) (Controls unexposed, sick), 2010 20.510.01.0