Lamotrigine (All indications) updated on 04-22-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8972
R30410		 Holmes (Lamotrigine) (Mixed indications), 2011 Neonatal death (first 28 days of life) 1st trimester prospective cohort unexposed, disease free Adjustment: No 0.60 [0.06;5.80] C 3/948   1/190 4 948
ref
Total 1 studies 0.60 [0.06;5.80] 4 948
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Holmes (Lamotrigine) (Mixed indications), 2011Holmes, 2011 1 0.60[0.06; 5.80]49480%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.60[0.06; 5.80]4948 -NAHolmes (Lamotrigine) (Mixed indications), 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.60[0.06; 5.80]4948 -NAHolmes (Lamotrigine) (Mixed indications), 2011 1 Tags Adjustment   - No  - No 0.60[0.06; 5.80]4948 -NAHolmes (Lamotrigine) (Mixed indications), 2011 1 All studiesAll studies 0.60[0.06; 5.80]4948 -NAHolmes (Lamotrigine) (Mixed indications), 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.60[0.06; 5.80]4948 -NAHolmes (Lamotrigine) (Mixed indications), 2011 10.510.01.0