Lamotrigine (All indications)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8904
R30087		 Aydin (Lamotrigine), 2020 Preeclampsia/ eclampsia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 3.31 [0.06;183.69] C 0/7   0/22 0 7
ref
S8963
R30352		 Cohen (Lamotrigine) (Mixed indications), 2019 Preeclampsia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.07 [0.88;1.29] 129/2,682   53,634/1,440,631 53,763 2,682
ref
S8958
R30339		 Borthen (Lamotrigine) (Controls unexposed, disease free), 2011 Pre-eclampsia during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No Matched 4.40 [1.50;13.00]
excluded (control group) 		6/30   11/205 17 30
ref
S8960
R30347		 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 Pre-eclampsia during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.77 [0.59;5.30] C 6/30   11/89 17 30
ref
Total 3 studies 1.09 [0.90;1.31] 53,780 2,719
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin (Lamotrigine), 2020Aydin, 2020 1 3.31[0.06; 183.69]070%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Cohen (Lamotrigine) (Mixed indications), 2019Cohen, 2019 2 1.07[0.88; 1.29]53,7632,68297%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Borthen (Lamotrigine) (Controls unexposed, sick), 2011Borthen, 2011 3 1.77[0.59; 5.30]17303%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.09[0.90; 1.31]53,7802,7190.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine; 2: Lamotrigine) (Mixed indications; 3: Lamotrigine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.90; 1.31]53,7802,7190%NAAydin (Lamotrigine), 2020 Cohen (Lamotrigine) (Mixed indications), 2019 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.07[0.88; 1.30]53,7632,682 -NACohen (Lamotrigine) (Mixed indications), 2019 1 unexposed, sickunexposed, sick 1.85[0.64; 5.32]17370%NAAydin (Lamotrigine), 2020 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 2 Tags Adjustment   - No  - No 1.85[0.64; 5.32]17370%NAAydin (Lamotrigine), 2020 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 2   - Yes  - Yes 1.07[0.88; 1.30]53,7632,682 -NACohen (Lamotrigine) (Mixed indications), 2019 1 All studiesAll studies 1.09[0.90; 1.31]53,7802,7190%NAAydin (Lamotrigine), 2020 Cohen (Lamotrigine) (Mixed indications), 2019 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8958

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.96[0.50; 7.70]53,7802,71284%NACohen (Lamotrigine) (Mixed indications), 2019 Borthen (Lamotrigine) (Controls unexposed, disease free), 2011 2 unexposed, sick controlsunexposed, sick controls 1.85[0.64; 5.32]17370%NAAydin (Lamotrigine), 2020 Borthen (Lamotrigine) (Controls unexposed, sick), 2011 20.510.01.0