Lamotrigine (All indications)

ADHD (Attention deficit hyperactivity disorder): Diagnosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15229
R62527		 Dreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Attention-deficit/hyperactivity disorder (ADHD) - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 0.83 [0.66;1.04] 95/5,288   528/22,203 623 5,288
ref
S8956
R30332		 Wiggs (Lamotrigine), 2020 Attention-deficit/hyperactivity disorder (after 2 years of age) at least 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.00 [0.59;1.69] -/-   -/11,298 - -
ref
S8933
R30194		 Bromley (Lamotrigine) (Controls unexposed, disease free), 2013 Attention deficit hyperactivity disorder (at 6 years old) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 7.24 [0.14;371.71] C
excluded (control group) 		0/30   0/214 0 30
ref
S8936
R30210		 Bromley (Lamotrigine) (Controls unexposed, sick), 2013 Attention deficit hyperactivity disorder (at 6 years old) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.86 [0.02;45.15] C 0/30   0/26 0 30
ref
Total 3 studies 0.85 [0.69;1.05] 623 5,318
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 0.83[0.66; 1.04]6235,28884%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wiggs (Lamotrigine), 2020Wiggs, 2020 2 1.00[0.59; 1.69]--16%ROB confusion: seriousROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Bromley (Lamotrigine) (Controls unexposed, sick), 2013Bromley, 2013 3 0.86[0.02; 45.15]0300%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.85[0.69; 1.05]6235,3180.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Epilepsy) (Controls unexposed, sick; 2: Lamotrigine; 3: Lamotrigine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.85[0.69; 1.05]6235,3180%NADreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Wiggs (Lamotrigine), 2020 Bromley (Lamotrigine) (Controls unexposed, sick), 2013 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.85[0.69; 1.05]6235,3180%NADreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Wiggs (Lamotrigine), 2020 Bromley (Lamotrigine) (Controls unexposed, sick), 2013 3 Tags Adjustment   - No  - No 0.86[0.02; 45.15]-30 -NABromley (Lamotrigine) (Controls unexposed, sick), 2013 1   - Yes  - Yes 0.85[0.69; 1.05]6235,2880%NADreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Wiggs (Lamotrigine), 2020 2 All studiesAll studies 0.85[0.69; 1.05]6235,3180%NADreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Wiggs (Lamotrigine), 2020 Bromley (Lamotrigine) (Controls unexposed, sick), 2013 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8933

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.24[0.14; 371.71]-30 -NABromley (Lamotrigine) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 0.85[0.69; 1.05]6235,3180%NADreier (Lamotrigine) (Epilepsy) (Controls unexposed, sick), 2023 Wiggs (Lamotrigine), 2020 Bromley (Lamotrigine) (Controls unexposed, sick), 2013 30.510.01.0