Topiramate (All indications) updated on 04-22-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19337
R81972		 Moore (Controls exposed to LTG) (Topiramate) (Indication NOS), 2025 Elective termination of pregnancy during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.48 [1.14;1.92] C
excluded (control group) 		94/365   351/1,846 445 365
ref
S19330
R81944		 Moore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 Elective termination of pregnancy during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 1.65 [1.22;2.23] 94/365   618/3,357 712 365
ref
Total 1 studies 1.65 [1.22;2.23] 712 365
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Moore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025Moore, 2025 1 1.65[1.22; 2.23]7123650%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: low0.55.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop) (Topiramate) (Indication NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 1 Tags Adjustment   - Yes  - Yes 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 1 MatchedMatched 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 1 All studiesAll studies 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 19337

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.65[1.22; 2.23]712365 -NAMoore (Controls unexposed, general pop) (Topiramate) (Indication NOS), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.48[1.14; 1.92]445365 -NAMoore (Controls exposed to LTG) (Topiramate) (Indication NOS), 2025 10.510.01.0