id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S12873 R48626 |
Thomas (Topiramate) (Controls exposed to Lamotrigine, sick), 2021 | Urinary malformations | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
1.90 [0.07;50.68] C excluded (control group) |
0/9 1/50 | 1 | 9 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12875 R48638 |
Thomas (Topiramate) (Controls unexposed, sick), 2021 | Urinary malformations | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 3.02 [0.16;58.01] C | 0/9 6/340 | 6 | 9 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8575 R28531 |
Tomson (Topiramate), 2018 | Renal malformations | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.97 [0.06;16.93] C | 0/152 8/2,514 | 8 | 152 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 1.68 [0.22;13.11] | 14 | 161 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Topiramate) (Controls unexposed, sick; 2: Topiramate;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 12873