Topiramate (All indications) updated on 04-22-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19392
R82390		 Honybun (Controls exposed to LTG) (Topiramate) (Epilepsy), 2026 Academic Outcomes: Math computation - Wide Range Achievement Test–Fifth Edition - Children aged 3–18 years (mean age about 10 years) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No extrapolated (cont. endpoint) 4.08 [0.92;18.16]
excluded (control group) 		-/9   -/19 - 9
ref
S19388
R82350		 Honybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Academic Outcomes: Math computation - Wide Range Achievement Test–Fifth Edition - Children aged 3–18 years (mean age about 10 years) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No extrapolated (cont. endpoint) 8.62 [1.58;46.94] -/9   -/13 - 9
ref
S19372
R82175		 Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Learning difficulty - ICD-10 codes: F81.0, F81.2, F81.8x, R48.0 - Mean follow up (full cohort): 3.4 years during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.59 [0.17;1.98] -/961   43/8,887 - 961
ref
Total 2 studies 2.11 [0.15;29.13] 0 970
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Honybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026Honybun, 2026 1 8.62[1.58; 46.94]-948%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: lowROB reporting: moderate Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026Straub, 2026 2 0.59[0.17; 1.98]-96152%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 84% 2.11[0.15; 29.13]-9700.220.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) (Topiramate) (Epilepsy; 2: Controls unexposed, sick) (Topiramate) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.11[0.15; 29.13]-97084%NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.11[0.15; 29.13]-97084%NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 2 Tags Adjustment   - No  - No 8.62[1.58; 46.98]-9 -NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 1   - Yes  - Yes 0.59[0.17; 2.01]-961 -NAStraub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 8.62[1.58; 46.98]-9 -NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 1 All studiesAll studies 2.11[0.15; 29.13]-97084%NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 19392

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.11[0.15; 29.13]3497084%NAHonybun (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 Straub (Controls unexposed, sick) (Topiramate) (Epilepsy), 2026 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.08[0.92; 18.13]-9 -NAHonybun (Controls exposed to LTG) (Topiramate) (Epilepsy), 2026 10.510.01.0