Topiramate (All indications)

ADHD (Attention deficit hyperactivity disorder): Diagnosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15240
R62665		 Dreier (Topiramate) (Epilepsy) (Controls exposed to LTG), 2023 Attention-deficit/hyperactivity disorder (ADHD) - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 3.19 [1.85;5.50] C
excluded (control group) 		16/290   95/5,288 111 290
ref
S15233
R62583		 Dreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 Attention-deficit/hyperactivity disorder (ADHD) - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 2.38 [1.40;4.06] 16/290   528/22,203 544 290
ref
Total 1 studies 2.38 [1.40;4.05] 544 290
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 2.38[1.40; 4.06]5442900%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.38[1.40; 4.05]544290 -NADreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.38[1.40; 4.05]544290 -NADreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 2.38[1.40; 4.05]544290 -NADreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 1 All studiesAll studies 2.38[1.40; 4.05]544290 -NADreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15240

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.38[1.40; 4.05]544290 -NADreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.19[1.85; 5.50]111290 -NADreier (Topiramate) (Epilepsy) (Controls exposed to LTG), 2023 10.510.01.0