id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S15251 R62709 |
Dudukina (Controls exposed to LTG) (Mixed indications), 2023 | Small for gestational age (birth weight below 2 standard deviations (SDs) of sex- and gestational week specific distributions) | 3 months (or more) before pregnancy or during pregnancy | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes |
0.95 [0.70;1.29] excluded (control group) |
-/2,382 -/7,130 | - | 2,382 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S15252 R62730 |
Dudukina (Controls unexposed, NOS) (Mixed indications), 2023 | Small for gestational age (birth weight below 2 standard deviations (SDs) of sex- and gestational week specific distributions) | 3 months (or more) before pregnancy or during pregnancy excluded | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes |
1.11 [0.88;1.40] excluded (exposition period) |
-/2,382 -/2,959,022 | - | 2,382 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8541 R28341 |
Coste (Controls unexposed, NOS) (Mixed indications), 2020 | Small for gestational age (weight) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 1.13 [0.96;1.32] C | 177/1,627 167,376/1,710,441 | 167,553 | 1,627 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8537 R28308 |
Kilic (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 | Small for gestational age (birth weight <10% percentile for the gestational birth week) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
3.07 [0.83;11.39] C excluded (control group) |
3/13 78/876 | 81 | 13 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8538 R28311 |
Kilic (Controls unexposed NOS) (Mixed indications), 2014 | Small for gestational age (birth weight <10% percentile for the gestational birth week) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: No |
2.80 [0.77;10.19] C excluded (control group) |
3/13 65,118/673,844 | 65,121 | 13 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8539 R28314 |
Kilic (Controls unexposed, sick) (Mixed indications), 2014 | Small for gestational age (birth weight <10% percentile for the gestational birth week) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: No Controls: epilepsy indication | 2.36 [0.65;8.61] C | 3/13 594/5,275 | 597 | 13 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 1.22 [0.77;1.93] | 168,150 | 1,640 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, NOS) (Mixed indications; 2: Controls unexposed, sick) (Mixed indications;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 8537, 8538, 15251