Pregabalin (All indications) updated on 04-22-2025

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19341
R82021		 Moore (Controls exposed to LTG) (Pregabalin) (Indication NOS), 2025 Gross motor disorders - Assessment offered to all children - At the 27–30 months during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.67 [1.08;2.60] C
excluded (control group) 		50/795   36/934 86 795
ref
S19335
R82042		 Moore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 Gross motor disorders - Assessment offered to all children - At the 27–30 months during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Matched 2.96 [2.15;4.09] C 50/795   176/7,949 226 795
ref
Total 1 studies 2.96 [2.15;4.09] 226 795
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Moore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025Moore, 2025 1 2.96[2.15; 4.09]2267950%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: low0.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop) (Pregabalin) (Indication NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 1 Tags Adjustment   - No  - No 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 1 MatchedMatched 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 1 All studiesAll studies 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 19341

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.96[2.15; 4.09]226795 -NAMoore (Controls unexposed, general pop) (Pregabalin) (Indication NOS), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.67[1.08; 2.60]86795 -NAMoore (Controls exposed to LTG) (Pregabalin) (Indication NOS), 2025 10.510.01.0