Pregabalin (All indications)

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10045
R36383		 Blotière (Controls exposed to Lamotrigine, sick) (Other indications), 2019 Craniosynostosis 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 12.58 [0.65;243.68] C
excluded (control group) 		3/1,671   0/2,997 3 1,671
ref
S10046
R36406		 Blotière (Controls unexposed NOS) (Other indications), 2019 Craniosynostosis 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 4.40 [0.90;13.00] 3/1,671   766/1,875,733 769 1,671
ref
Total 1 studies 4.40 [1.16;16.72] 769 1,671
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Controls unexposed NOS) (Other indications), 2019Blotière, 2019 1 4.40[0.90; 13.00]7691,6710%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS) (Other indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.40[1.16; 16.72]7691,671 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.40[1.16; 16.72]7691,671 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 Tags Adjustment   - No  - No 4.40[1.16; 16.72]7691,671 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 All studiesAll studies 4.40[1.16; 16.72]7691,671 -NABlotière (Controls unexposed NOS) (Other indications), 2019 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10045

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.40[1.16; 16.72]7691,671 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale12.58[0.65; 243.68]31,671 -NABlotière (Controls exposed to Lamotrigine, sick) (Other indications), 2019 10.510.01.0