Gabapentin (All indications)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8500
R27931		 Vajda (Controls exposed to Lamotrigine, sick), 2018 Intrauterine foetal death throughout pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.94 [0.05;16.57] C
excluded (control group) 		0/14   14/382 14 14
ref
S8501
R27932		 Vajda (Controls unexposed, sick), 2018 Intrauterine foetal death throughout pregnancy prospective cohort unexposed, sick Adjustment: No 4.16 [0.16;107.12] C 0/14   1/170 1 14
ref
S8490
R27884		 Miškov (Controls exposed to Lamotrigine, sick), 2016 Fetal loss during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 2.41 [0.08;68.55] C
excluded (control group) 		0/2   4/37 4 2
ref
S8491
R27890		 Miškov (Controls unexposed, disease free), 2016 Fetal loss during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 85.00 [1.23;5885.76] C
excluded (control group) 		0/2   0/128 0 2
ref
S8492
R27896		 Miškov (Controls unexposed, sick), 2016 Fetal loss during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.33 [0.03;182.92] C 0/2   0/4 0 2
ref
S8485
R27853		 Arkilo, 2015 Unsuccessful pregnancies (miscarriages/stillbirths) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 8.60 [0.14;536.34] C 0/1   2/24 2 1
ref
Total 3 studies 4.41 [0.49;39.98] 3 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vajda (Controls unexposed, sick), 2018Vajda, 2018 1 4.16[0.16; 107.12]11446%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Miškov (Controls unexposed, sick), 2016Miškov, 2016 2 2.33[0.03; 182.92]0226%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Arkilo, 2015Arkilo, 2015 8.60[0.14; 536.34]2128%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 4.41[0.49; 39.98]3170.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.41[0.49; 39.98]3170%NAVajda (Controls unexposed, sick), 2018 Miškov (Controls unexposed, sick), 2016 Arkilo, 2015 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.38[0.25; 45.81]1160%NAVajda (Controls unexposed, sick), 2018 Miškov (Controls unexposed, sick), 2016 2 exposed to other treatment, sickexposed to other treatment, sick 8.60[0.14; 536.34]21 -NAArkilo, 2015 1 Tags Adjustment   - No  - No 4.41[0.49; 39.98]3170%NAVajda (Controls unexposed, sick), 2018 Miškov (Controls unexposed, sick), 2016 Arkilo, 2015 3 All studiesAll studies 4.41[0.49; 39.98]3170%NAVajda (Controls unexposed, sick), 2018 Miškov (Controls unexposed, sick), 2016 Arkilo, 2015 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8490, 8491, 8500

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale85.00[1.23; 5885.76]-2 -NAMiškov (Controls unexposed, disease free), 2016 1 unexposed, sick controlsunexposed, sick controls 3.38[0.25; 45.81]1160%NAVajda (Controls unexposed, sick), 2018 Miškov (Controls unexposed, sick), 2016 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.08[0.30; 14.28]20170%NAVajda (Controls exposed to Lamotrigine, sick), 2018 Miškov (Controls exposed to Lamotrigine, sick), 2016 Arkilo, 2015 30.510.01.0