Oxazepam (Epilepsy) updated on 02-10-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8279
R26221		 Mawer (Epilepsy) (Controls exposed to Lamotrigine, sick), 2010 Major malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 13.80 [0.22;853.65] C
excluded (control group) 		0/1   2/37 2 1
ref
S8280
R26222		 Mawer (Epilepsy) (Controls unexposed, disease free), 2010 Major malformations 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No Matched 42.85 [0.79;2330.91] C
excluded (control group) 		0/1   6/285 6 1
ref
S8281
R26223		 Mawer (Epilepsy) (Controls unexposed, sick), 2010 Major malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 26.33 [0.38;1837.92] C 0/1   1/41 1 1
ref
Total 1 studies 26.33 [0.38;1837.92] 1 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Mawer (Epilepsy) (Controls unexposed, sick), 2010Mawer, 2010 1 26.33[0.38; 1837.92]110%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 26.33[0.38; 1837.92]11 -NAMawer (Epilepsy) (Controls unexposed, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 26.33[0.38; 1837.92]11 -NAMawer (Epilepsy) (Controls unexposed, sick), 2010 1 Tags Adjustment   - No  - No 26.33[0.38; 1837.92]11 -NAMawer (Epilepsy) (Controls unexposed, sick), 2010 1 All studiesAll studies 26.33[0.38; 1837.92]11 -NAMawer (Epilepsy) (Controls unexposed, sick), 2010 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8279, 8280

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale42.85[0.79; 2330.91]61 -NAMawer (Epilepsy) (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls Out of scale26.33[0.38; 1837.92]11 -NAMawer (Epilepsy) (Controls unexposed, sick), 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale13.80[0.22; 853.65]21 -NAMawer (Epilepsy) (Controls exposed to Lamotrigine, sick), 2010 10.510.01.0