Methsuximide (Epilepsy = ALL)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6714
R26937		 Samrén (Methsuximide), 1999 Major congential abnormalities at least 1st trimester retrospective cohort unexposed, disease free Adjustment: No Matched 66.80 [1.30;3423.69] C 0/1   29/2,000 29 1
ref
Total 1 studies 66.80 [1.30;3423.69] 29 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Samrén (Methsuximide), 1999Samrén, 1999 1 66.80[1.30; 3423.69]2910%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9500.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Methsuximide;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 1 Tags Adjustment   - No  - No 66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 1 MatchedMatched 66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 1 All studiesAll studies 66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 10.51000.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale66.80[1.30; 3423.69]291 -NASamrén (Methsuximide), 1999 10.510.01.0