Clobazam (Epilepsy) updated on 02-10-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8066
R24572		 Trivedi (Epilepsy) (Controls exposed to Lamotrigine, sick), 2018 Spontaneous fetal loss (both spontaneous abortion before 20 weeks of gestation and stillbirths occurring after 20 weeks of gestation) 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.10 [0.11;10.93] C
excluded (control group) 		1/11   4/48 5 11
ref
S8056
R24562		 Trivedi (Epilepsy) (Controls unexposed, sick), 2018 Spontaneous fetal loss (both spontaneous abortion before 20 weeks of gestation and stillbirths occurring after 20 weeks of gestation) 1st trimester prospective cohort unexposed, sick Adjustment: Yes 8.54 [0.62;117.93] 1/11   5/178 6 11
ref
Total 1 studies 8.54 [0.62;117.78] 6 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Trivedi (Epilepsy) (Controls unexposed, sick), 2018Trivedi, 2018 1 8.54[0.62; 117.93]6110%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.54[0.62; 117.78]611 -NATrivedi (Epilepsy) (Controls unexposed, sick), 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 8.54[0.62; 117.78]611 -NATrivedi (Epilepsy) (Controls unexposed, sick), 2018 1 Tags Adjustment   - Yes  - Yes 8.54[0.62; 117.78]611 -NATrivedi (Epilepsy) (Controls unexposed, sick), 2018 1 All studiesAll studies 8.54[0.62; 117.78]611 -NATrivedi (Epilepsy) (Controls unexposed, sick), 2018 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8066

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 8.54[0.62; 117.78]611 -NATrivedi (Epilepsy) (Controls unexposed, sick), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.10[0.11; 10.93]511 -NATrivedi (Epilepsy) (Controls exposed to Lamotrigine, sick), 2018 10.510.01.0