Clobazam (Epilepsy) updated on 02-10-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12866
R48562		 Thomas (Epilepsy) (Controls exposed to Lamotrigine, sick), 2021 Cardiac malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.20 [0.05;31.10] C
excluded (control group) 		0/14   1/50 1 14
ref
S12867
R48572		 Thomas (Epilepsy) (Controls unexposed, sick), 2021 Cardiac malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 1.29 [0.07;23.31] C 0/14   9/340 9 14
ref
Total 1 studies 1.29 [0.07;23.31] 9 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas (Epilepsy) (Controls unexposed, sick), 2021Thomas, 2021 1 1.29[0.07; 23.31]9140%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.29[0.07; 23.31]914 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.29[0.07; 23.31]914 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 1.29[0.07; 23.31]914 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 All studiesAll studies 1.29[0.07; 23.31]914 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12866

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.29[0.07; 23.31]914 -NAThomas (Epilepsy) (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.20[0.05; 31.10]114 -NAThomas (Epilepsy) (Controls exposed to Lamotrigine, sick), 2021 10.510.01.0