Vigabatrin (Epilepsy)

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6069
R15792		 Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 Facial cleft 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 39.12 [1.43;1070.14] C 0/6   1/647 1 6
ref
Total 1 studies 39.12 [1.43;1070.14] 1 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006Morrow, 2006 1 39.12[1.43; 1070.14]160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Vigabatrin) (Controls exposed to Lamotrigine, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 39.12[1.43; 1070.14]16 -NAMorrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 39.12[1.43; 1070.14]16 -NAMorrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 1 Tags Adjustment   - No  - No 39.12[1.43; 1070.14]16 -NAMorrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 1 All studiesAll studies 39.12[1.43; 1070.14]16 -NAMorrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale39.12[1.43; 1070.14]16 -NAMorrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 10.510.01.0