Phenobarbital (Epilepsy)

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7981
R24256		 Coste (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2020 Neonatal condition during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 0.85 [0.42;1.71] C
excluded (control group) 		9/84   349/2,813 358 84
ref
S7809
R23147		 Coste (Phenobarbital) (Controls unexposed, NOS), 2020 Neonatal condition during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.80 [0.40;1.60] C 9/84   222,201/1,710,441 222,210 84
ref
S6686
R18636		 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 1.22 [0.06;26.35] C
excluded (control group) 		0/4   6/62 6 4
ref
S6694
R18797		 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, sick Adjustment: No 0.31 [0.01;8.68] C 0/4   2/8 2 4
ref
Total 2 studies 0.77 [0.39;1.52] 222,212 88
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Phenobarbital) (Controls unexposed, NOS), 2020Coste, 2020 1 0.80[0.40; 1.60]222,2108496%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Phenobarbital) (Controls unexposed, sick), 1991D'Souza, 1991 2 0.31[0.01; 8.68]244%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.77[0.39; 1.52]222,212880.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, NOS; 2: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.77[0.39; 1.52]222,212880%NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.40; 1.60]222,21084 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 1 unexposed, sickunexposed, sick 0.31[0.01; 8.68]24 -NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 0.77[0.39; 1.52]222,212880%NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 All studiesAll studies 0.77[0.39; 1.52]222,212880%NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6686, 7981

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.82[0.42; 1.61]222,216880%NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls Out of scale0.31[0.01; 8.68]24 -NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.85[0.42; 1.71]35884 -NACoste (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2020 10.510.01.0