Phenobarbital (Epilepsy)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7981
R24253		 Coste (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2020 Weight at birth <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 2.56 [1.36;4.81] C
excluded (control group) 		12/84   172/2,813 184 84
ref
S7809
R23144		 Coste (Phenobarbital) (Controls unexposed, NOS), 2020 Weight at birth <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.95 [1.60;5.44] C 12/84   91,455/1,710,441 91,467 84
ref
Total 1 studies 2.95 [1.60;5.44] 91,467 84
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Phenobarbital) (Controls unexposed, NOS), 2020Coste, 2020 1 2.95[1.60; 5.44]91,467840%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.95[1.60; 5.44]91,46784 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.95[1.60; 5.44]91,46784 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 1 Tags Adjustment   - No  - No 2.95[1.60; 5.44]91,46784 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 1 All studiesAll studies 2.95[1.60; 5.44]91,46784 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 7981

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.95[1.60; 5.44]91,46784 -NACoste (Phenobarbital) (Controls unexposed, NOS), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.56[1.36; 4.81]18484 -NACoste (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2020 10.510.01.0