Phenobarbital (Epilepsy)

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7660
R22661		 Tomson (Phenobarbital), 2018 Cleft lip or palate at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 2.86 [0.30;27.55] C 1/294   3/2,514 4 294
ref
S5941
R23806		 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 Oral clefts 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No Controls: mixed indications 4.56 [1.32;15.71] C 4/199   7/1,562 11 199
ref
Total 2 studies 4.09 [1.38;12.13] 15 493
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tomson (Phenobarbital), 2018Tomson, 2018 1 2.86[0.30; 27.55]429423%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012Hernández-Díaz, 2012 2 4.56[1.32; 15.71]1119977%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 4.09[1.38; 12.13]154930.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital; 2: Phenobarbital) (Controls exposed to Lamotrigine, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.09[1.38; 12.13]154930%NATomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 4.09[1.38; 12.13]154930%NATomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 2 Tags Adjustment   - No  - No 4.09[1.38; 12.13]154930%NATomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 2 Controls   - mixed indications  - mixed indications 4.56[1.32; 15.71]11199 -NAHernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 1 All studiesAll studies 4.09[1.38; 12.13]154930%NATomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.09[1.38; 12.13]154930%NATomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 20.510.01.0