Phenobarbital (Epilepsy)

Hip dislocation and/or dysplasia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6686
R18614		 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Dislocation of hip throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 17.57 [0.30;1024.08] C
excluded (control group) 		0/4   0/62 0 4
ref
S6694
R18775		 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Dislocation of hip throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.14 [0.03;131.94] C 0/4   0/8 0 4
ref
S5526
R19272		 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 Dysplasia of the hips throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 15.57 [0.59;408.94] C
excluded (control group) 		1/12   0/55 1 12
ref
S6824
R19322		 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 Dysplasia of the hips throughout pregnancy prospective cohort unexposed, sick Adjustment: No 6.14 [0.23;164.01] C 1/12   0/22 1 12
ref
Total 2 studies 4.08 [0.31;53.22] 1 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF D'Souza (Phenobarbital) (Controls unexposed, sick), 1991D'Souza, 1991 1 2.14[0.03; 131.94]0439%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991Van der Pol, 1991 2 6.14[0.23; 164.01]11261%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 4.08[0.31; 53.22]1160.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick; 2: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.08[0.31; 53.22]1160%NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.08[0.31; 53.22]1160%NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 4.08[0.31; 53.22]1160%NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 All studiesAll studies 4.08[0.31; 53.22]1160%NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6686, 5526

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale16.33[1.28; 208.51]1160%NAD'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 4.08[0.31; 53.22]1160%NAD'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0