Oxcarbazepine (Epilepsy)

Late intrauterine deaths (> 22 weeks)

id	Study   Auto AlSheikh (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2020AlSheikh (Oxcarbazepine) (Controls unexposed, sick), 2020Aydin (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2020Aydin (Oxcarbazepine) (Controls unexposed, sick), 2020Tomson (Oxcarbazepine), 2015	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S7959 R24146	AlSheikh (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2020	Stillbirth	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	7.80 [0.12;487.53] C excluded (control group)	0/3   0/20	0	3		ref
S7957 R24118	AlSheikh (Oxcarbazepine) (Controls unexposed, sick), 2020	Stillbirth	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	3.00 [0.05;194.76] C	0/3   0/8	0	3		ref
S8084 R24703	Aydin (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2020	Intrauterine fetal demise	throughout pregnancy	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.86 [0.03;115.45] C excluded (control group)	0/4   0/7	0	4		ref
S8075 R24643	Aydin (Oxcarbazepine) (Controls unexposed, sick), 2020	Intrauterine fetal demise	throughout pregnancy	retrospective cohort	unexposed, sick	Adjustment: No	6.14 [0.10;363.16] C	0/4   0/22	0	4		ref
S7816 R23214	Tomson (Oxcarbazepine), 2015	Stillbirths	at least 1st trimester	prospective cohort	exposed to other treatment, sick	Adjustment: No	2.44 [0.49;12.16] C	2/262   6/1,910	8	262		ref
					Total	3 studies	2.79 [0.68;11.38]		8	269
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 7959, 8084