Oxcarbazepine (Epilepsy)

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6170
R21991		 Viinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Cleft lip throughout pregnancy prospective cohort unexposed, sick Adjustment: No 34.33 [0.49;2389.88] C 0/2   0/52 0 2
ref
S6096
R15870		 Artama (Oxcarbazepine), 2005 Cleft lip/ cleft palate 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 1.90 [0.09;39.89] C 0/99   2/939 2 99
ref
Total 2 studies 5.45 [0.36;83.53] 2 101
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Viinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006Viinikainen, 2006 1 34.33[0.49; 2389.88]0236%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Artama (Oxcarbazepine), 2005Artama, 2005 2 1.90[0.09; 39.89]29964%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 15% 5.45[0.36; 83.53]21010.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oxcarbazepine) (Controls unexposed, sick) ; 2: Oxcarbazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.45[0.36; 83.53]210115%NAViinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Artama (Oxcarbazepine), 2005 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 5.45[0.36; 83.53]210115%NAViinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Artama (Oxcarbazepine), 2005 2 Tags Adjustment   - No  - No 5.45[0.36; 83.53]210115%NAViinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Artama (Oxcarbazepine), 2005 2 All studiesAll studies 5.45[0.36; 83.53]210115%NAViinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Artama (Oxcarbazepine), 2005 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 5.45[0.36; 83.53]210115%NAViinikainen (Oxcarbazepine) (Controls unexposed, sick) a, 2006 Artama (Oxcarbazepine), 2005 20.510.01.0