Lamotrigine (Epilepsy)

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8077
R24651		 Aydin, 2020 Large for gestational age (birth weight) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 11.73 [0.42;329.24] C 1/7   0/22 1 7
ref
S5912
R14925		 Artama (Controls unexposed, disease free), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 0.42 [0.10;1.68]
excluded (control group) 		2/173   21,574/719,509 21,576 173
ref
S5920
R15021		 Artama (Controls unexposed, sick), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.36 [0.08;1.52] 2/173   71/1,793 73 173
ref
Total 2 studies 1.47 [0.05;41.93] 74 180
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin, 2020Aydin, 2020 11.73[0.42; 329.24]1740%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Artama (Controls unexposed, sick), 2013Artama, 2013 1 0.36[0.08; 1.52]7317360%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 71% 1.47[0.05; 41.93]741800.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.47[0.05; 41.93]7418071%NAAydin, 2020 Artama (Controls unexposed, sick), 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.47[0.05; 41.93]7418071%NAAydin, 2020 Artama (Controls unexposed, sick), 2013 2 Tags Adjustment   - No  - No 11.73[0.42; 329.24]17 -NAAydin, 2020 1   - Yes  - Yes 0.36[0.08; 1.57]73173 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 1.47[0.05; 41.93]7418071%NAAydin, 2020 Artama (Controls unexposed, sick), 2013 20.150.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5912

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.42[0.10; 1.72]21,576173 -NAArtama (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 1.47[0.05; 41.93]7418071%NAAydin, 2020 Artama (Controls unexposed, sick), 2013 20.510.01.0