Lamotrigine (Epilepsy) updated on 04-22-2025

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12612
R47533		 Van Marter (Controls unexposed, disease free), 2021 Prematurity - Moderate (28-33 wk gestational age) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 0.96 [0.06;15.60] C
excluded (control group) 		1/110   1/106 2 110
ref
S12614
R47545		 Van Marter (Controls unexposed, sick), 2021 Prematurity - Moderate (28-33 wk gestational age) at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.13 [0.01;2.17] C 1/110   1/15 2 110
ref
Total 1 studies 0.13 [0.01;2.17] 2 110
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van Marter (Controls unexposed, sick), 2021Van Marter, 2021 1 0.13[0.01; 2.17]21100%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.13[0.01; 2.17]2110 -NAVan Marter (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.13[0.01; 2.17]2110 -NAVan Marter (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 0.13[0.01; 2.17]2110 -NAVan Marter (Controls unexposed, sick), 2021 1 All studiesAll studies 0.13[0.01; 2.17]2110 -NAVan Marter (Controls unexposed, sick), 2021 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12612

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.06; 15.60]2110 -NAVan Marter (Controls unexposed, disease free), 2021 1 unexposed, sick controlsunexposed, sick controls Out of scale0.13[0.01; 2.17]2110 -NAVan Marter (Controls unexposed, sick), 2021 10.510.01.0