Lamotrigine (Epilepsy)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12515
R47141		 Hosny, 2021 Induced abortion 1st trimester prospective cohort unexposed, sick Adjustment: No 8.20 [0.13;511.93] C 0/3   0/21 0 3
ref
S5546
R18861		 Miškov (Controls unexposed, disease free), 2016 Artificial abortion during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 10.77 [0.43;270.26] C
excluded (control group) 		1/37   0/128 1 37
ref
S7411
R21811		 Miškov (Controls unexposed, sick), 2016 Artificial abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.30 [0.01;8.72] C 1/37   0/4 1 37
ref
Total 2 studies 1.25 [0.05;31.47] 1 40
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hosny, 2021Hosny, 2021 8.20[0.13; 511.93]0343%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: lowROB mesure: unclearROB reporting: moderate Miškov (Controls unexposed, sick), 2016Miškov, 2016 1 0.30[0.01; 8.72]13757%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 33% 1.25[0.05; 31.47]1400.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.25[0.05; 31.47]14033%NAHosny, 2021 Miškov (Controls unexposed, sick), 2016 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.25[0.05; 31.47]14033%NAHosny, 2021 Miškov (Controls unexposed, sick), 2016 2 Tags Adjustment   - No  - No 1.25[0.05; 31.47]14033%NAHosny, 2021 Miškov (Controls unexposed, sick), 2016 2 All studiesAll studies 1.25[0.05; 31.47]14033%NAHosny, 2021 Miškov (Controls unexposed, sick), 2016 20.120.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5546

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.77[0.43; 270.26]137 -NAMiškov (Controls unexposed, disease free), 2016 1 unexposed, sick controlsunexposed, sick controls 1.25[0.05; 31.47]14033%NAHosny, 2021 Miškov (Controls unexposed, sick), 2016 20.510.01.0