Lamotrigine (Epilepsy)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8003
R24375		 AlSheikh, 2020 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.38 [0.01;21.20] C 0/20   0/8 0 20
ref
S8077
R24653		 Aydin, 2020 Intrauterine fetal demise throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 3.31 [0.06;183.69] C 0/7   0/22 0 7
ref
Total 2 studies 1.13 [0.07;19.22] 0 27
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF AlSheikh, 2020AlSheikh, 2020 0.38[0.01; 21.20]02050%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Aydin, 2020Aydin, 2020 3.31[0.06; 183.69]0750%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.13[0.07; 19.22]-270.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.13[0.07; 19.22]-270%NAAlSheikh, 2020 Aydin, 2020 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.13[0.07; 19.22]-270%NAAlSheikh, 2020 Aydin, 2020 2 Tags Adjustment   - No  - No 1.13[0.07; 19.22]-270%NAAlSheikh, 2020 Aydin, 2020 2 All studiesAll studies 1.13[0.07; 19.22]-270%NAAlSheikh, 2020 Aydin, 2020 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.13[0.07; 19.22]-270%NAAlSheikh, 2020 Aydin, 2020 20.510.01.0